Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice (2024)

Huang, F., Marungruang, N., Kostiuchenko, O., Kravchenko, N., Burleigh, S., Prykhodko, O., Hållenius, F. F. (2022). Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice. Nutrients, 14(13). https://doi.org/10.3390/nu14132734

Huang, Fang ; Marungruang, Nittaya ; Kostiuchenko, Olha et al. / Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice. In: Nutrients. 2022 ; Vol. 14, No. 13.

@article{4da4afd02b064ef1a2d83d44ebe181b2,

title = "Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice",

abstract = "High-fat diets are associated with neuronal and memory dysfunction. Berries may be useful in improving age-related memory deficits in humans, as well as in mice receiving high-fat diets. Emerging research has also demonstrated that brain health and cognitive function may be related to the dynamic changes in the gut microbiota. In this study, the impact of Nordic berries on the brain and the gut microbiota was investigated in middle-aged C57BL/6J mice. The mice were fed high-fat diets (60%E fat) supplemented with freeze-dried powder (6% dwb) of bilberry, lingonberry, cloudberry, blueberry, blackcurrant, and sea buckthorn for 4 months. The results suggest that supplementation with bilberry, blackcurrant, blueberry, lingonberry, and (to some extent) cloudberry has beneficial effects on spatial cognition, as seen by the enhanced performance following the T-maze alternation test, as well as a greater proportion of DCX-expressing cells with prolongation in hippocampus. Furthermore, the proportion of the mucosa-associated symbiotic bacteria Akkermansia muciniphila increased by 4-14 times in the cecal microbiota of mice fed diets supplemented with lingonberry, bilberry, sea buckthorn, and blueberry. These findings demonstrate the potential of Nordic berries to preserve memory and cognitive function, and to induce alterations of the gut microbiota composition. ",

keywords = "Animals, Blueberry Plants, Cognition, Diet, High-Fat/adverse effects, Fruit, Gastrointestinal Microbiome, Mice, Mice, Inbred C57BL, Vaccinium myrtillus, Verrucomicrobia",

author = "Fang Huang and Nittaya Marungruang and Olha Kostiuchenko and Nadiia Kravchenko and Stephen Burleigh and Olena Prykhodko and H{\aa}llenius, {Frida F{\aa}k} and Lovisa Heyman-Lind{\'e}n",

year = "2022",

month = jun,

day = "30",

doi = "10.3390/nu14132734",

language = "English",

volume = "14",

journal = "Nutrients",

issn = "2072-6643",

publisher = "MDPI AG",

number = "13",

}

Huang, F, Marungruang, N, Kostiuchenko, O, Kravchenko, N, Burleigh, S, Prykhodko, O, Hållenius, FF 2022, 'Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice', Nutrients, vol. 14, no. 13. https://doi.org/10.3390/nu14132734

Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice. / Huang, Fang; Marungruang, Nittaya; Kostiuchenko, Olha et al.
In: Nutrients, Vol. 14, No. 13, 30.06.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice

AU - Huang, Fang

AU - Marungruang, Nittaya

AU - Kostiuchenko, Olha

AU - Kravchenko, Nadiia

AU - Burleigh, Stephen

AU - Prykhodko, Olena

AU - Hållenius, Frida Fåk

AU - Heyman-Lindén, Lovisa

PY - 2022/6/30

Y1 - 2022/6/30

N2 - High-fat diets are associated with neuronal and memory dysfunction. Berries may be useful in improving age-related memory deficits in humans, as well as in mice receiving high-fat diets. Emerging research has also demonstrated that brain health and cognitive function may be related to the dynamic changes in the gut microbiota. In this study, the impact of Nordic berries on the brain and the gut microbiota was investigated in middle-aged C57BL/6J mice. The mice were fed high-fat diets (60%E fat) supplemented with freeze-dried powder (6% dwb) of bilberry, lingonberry, cloudberry, blueberry, blackcurrant, and sea buckthorn for 4 months. The results suggest that supplementation with bilberry, blackcurrant, blueberry, lingonberry, and (to some extent) cloudberry has beneficial effects on spatial cognition, as seen by the enhanced performance following the T-maze alternation test, as well as a greater proportion of DCX-expressing cells with prolongation in hippocampus. Furthermore, the proportion of the mucosa-associated symbiotic bacteria Akkermansia muciniphila increased by 4-14 times in the cecal microbiota of mice fed diets supplemented with lingonberry, bilberry, sea buckthorn, and blueberry. These findings demonstrate the potential of Nordic berries to preserve memory and cognitive function, and to induce alterations of the gut microbiota composition.

AB - High-fat diets are associated with neuronal and memory dysfunction. Berries may be useful in improving age-related memory deficits in humans, as well as in mice receiving high-fat diets. Emerging research has also demonstrated that brain health and cognitive function may be related to the dynamic changes in the gut microbiota. In this study, the impact of Nordic berries on the brain and the gut microbiota was investigated in middle-aged C57BL/6J mice. The mice were fed high-fat diets (60%E fat) supplemented with freeze-dried powder (6% dwb) of bilberry, lingonberry, cloudberry, blueberry, blackcurrant, and sea buckthorn for 4 months. The results suggest that supplementation with bilberry, blackcurrant, blueberry, lingonberry, and (to some extent) cloudberry has beneficial effects on spatial cognition, as seen by the enhanced performance following the T-maze alternation test, as well as a greater proportion of DCX-expressing cells with prolongation in hippocampus. Furthermore, the proportion of the mucosa-associated symbiotic bacteria Akkermansia muciniphila increased by 4-14 times in the cecal microbiota of mice fed diets supplemented with lingonberry, bilberry, sea buckthorn, and blueberry. These findings demonstrate the potential of Nordic berries to preserve memory and cognitive function, and to induce alterations of the gut microbiota composition.

KW - Animals

KW - Blueberry Plants

KW - Cognition

KW - Diet, High-Fat/adverse effects

KW - Fruit

KW - Gastrointestinal Microbiome

KW - Mice

KW - Mice, Inbred C57BL

KW - Vaccinium myrtillus

KW - Verrucomicrobia

U2 - 10.3390/nu14132734

DO - 10.3390/nu14132734

M3 - Article

C2 - 35807915

SN - 2072-6643

VL - 14

JO - Nutrients

JF - Nutrients

IS - 13

ER -

Huang F, Marungruang N, Kostiuchenko O, Kravchenko N, Burleigh S, Prykhodko O et al. Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice. Nutrients. 2022 Jun 30;14(13). doi: 10.3390/nu14132734